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Previous study demonstrated that resveratrol is a sirtuin-1 (SIRT1) enhancer, which is the positive regulator of wnt signaling that is very important for neurogenesis, in addition to upregulation of the AMPK pathway, which, in turn, promotes mitochondrial biogenesis, enhances autophagic clearance of protein aggregates, and upregulates BDNF expression (Surya et al., 2023)
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