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At the cellular level, studies in rodent colon anastomosis models have reported: Increased collagen organization and tensile strength at anastomosis sites Enhanced fibroblast migration and proliferation rates versus control cohorts Suppressed NF-κB–driven cytokine expression (IL-6, TNF-α) in inflamed mucosal tissue Accelerated intestinal fistula closure in cysteamine-induced ulcer models Gastrointestinal research evidence BPC-157 has the deepest published record of any peptide in the gut-healing research space

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