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Consequently, the final clue may be that BPC 157 acts via increasing tight junction protein ZO-1 expression, and transepithelial resistance, inhibiting the mRNA of inflammatory mediators (iNOS, IL-6, IFNγ, and TNF-α), and increasing the expression of HSP 70 and 90, and antioxidant proteins, such as HO-1,NQO-1, glutathione reductase, glutathione peroxidase 2, and GST-pi, and counteracting leaky gut syndrome [4]

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[DOI] [PubMed] [Google Scholar] 133.Lei T.C., Virador V.M., Vieira W.D., Hearing V.J