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GSH exhibits multiple antioxidant actions, involving direct conjugation with free radicals such as ROS and reactive nitrogen species 46 and enzyme-mediated neutralization of free radicals, including GSH peroxidase (GPx), which detoxifies peroxides with GSH acting as an electron donor 47

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For example, air pollution has been reported to trigger ROS production in the conjunctiva and cornea, contributing to DED [56]