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ABSTRACTS - 2026 - Movement Disorders Clinical Practice - Wiley Online Library

Exposure to mitragynine at 40 and 60 μM for 48 h reduced the viability of human aortic endothelial cells, which was linked to an increase in intracellular reactive oxygen species (ROS) production, leading to caspase-3 activation, DNA fragmentation, and apoptosis (Matsunaga et al., 2017)

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