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The Discovery — Rabbit Thalamic Stimulation (1977) The original 1977 isolation by the Schoenenberger-Monnier group at Basel confirmed DSIP as a nonapeptide of MW 849 Da inducing primarily delta-sleep in rabbits, rats, mice, and humans — with a more pronounced effect on REM sleep observed in cats — establishing the species-dependent variation in DSIP’s sleep-promoting profile that remains relevant to experimental design today

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