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However, the clinical benefit of this modality has still been limited due to several defects such as adverse events, acquired drug resistance, tumor recurrence, and lack of validated biomarkers, which impel further research on mechanisms of tumor angiogenesis, the development of multiple drugs and the combination therapy to figure out how to improve the therapeutic efficacy

Hypovolemic States

Menge:3 STÜCK

Neurologic Diseases The nervous system, particularly the brain, is highly vulnerable to oxidative damage due to its high energy and oxygen consumption, the large concentration of PUFAs in myelin membranes, and its relatively low antioxidant defenses [180,181]