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Activation of the Transcription Factor NRF2 by Polyphenols, Vitamins, and Selenium The nuclear factor erythroid 2-related factor 2 (NRF2) responds to the OS by binding to the regions of genes that control the antioxidant response (ARE), and the NRF2/ARE induction pathway is of great interest due to its activation by phytochemical compounds [147]

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Regulator of G-protein signaling 10 negatively regulates cardiac remodeling by blocking mitogen-activated protein kinase-extracellular signal-regulated protein kinase 1/2 signaling