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The engagement of the PD-1 receptor with PD-L1 activates PD-1 downstream from Src homology region 2 domain-containing protein tyrosine phosphatase (SHP-2) and dephosphorylates ZAP70, leading to the inhibition of T cell survival, proliferation and cytokine production, inducing T-cell exhaustion

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doi: 10.1016/j.exphem.2016.08.005 105 LambertJSalibaJCalderonCSii-FeliceKSalmaMEdmondVet al