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γ-glutamylcysteine synthetase inhibitor, buthionine sulfoximine (BSO) or the cystine/glutamate antiporter inhibitor erastin (ERA), synergize with thioredoxin reductase (TrxR) inhibitor auranofin (AUR) to induce cell death in RMS cells

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While existing evidence underscores the multi-target potential of B vitamins in preventing and treating LLD, it remains essential to establish a therapeutic window and biomarker-guided personalized application strategies through standardized intervention trials