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FIGURE 3 Vitamin B12 Inhibited Microtubule Damage Through ER Stress After TBI Numerous studies have indicated that vitamin B12 has neuroprotective effects on TBI (Figure 4A–C, the expressions of MAP-2 and Tau decreased after injury, and the Tau expression was significantly higher in the vitamin B12-treated group relative to the TBI group after 7 days

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