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Here, we show that impaired OGDHc activity (via ABHD11 inhibition) in human CD8 + lymphocytes has distinct effects from those observed in cancer cells, with the perturbed TCA cycle driving synthesis of unsaturated fatty acids, rather than the accumulation of 2-HG that inhibits 2-OGDDs
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An alternative to enemas is administration of an oral polyethylene glycol (PEG 3350) solution (e.g., CoLyte, GoLytely)
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