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The initial model was rigid-body fitted into the consensus EM density map via UCSF Chimera 1.14 32 , followed by manual adjustment using ISOLDE 33 embedded in UCSF ChimeraX 1.6 34

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Fifteen years later Maquart and colleagues noted that the same GHK triplet occurs within the alpha-2 chain of type I collagen, and proposed that proteolysis at a site of tissue damage could liberate the sequence locally

and the healthy functioning of the liver