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Second , we provided evidence that the AR -/lo subtype of CRPC (such as LAPC9-AI and CRPC_Wnt and CRPC_NE) may upregulate BCL-2 not only through the loss of AR-mediated repression but also through increased chromatin accessibility, but little is known about what TFs might be actively transcribing the BCL-2 via these open chromatin loci in AR -/lo CRPC cells