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The mice with hyper-long telomeres exhibited reduced DNA damage with aging, improved metabolic markers such as lower LDL levels, improved glucose and insulin tolerance, decreased cancer incidence, and increased longevity ( 3.1.3 Tankyrase inhibitors Tankyrase inhibitors are molecules designed to inhibit the function of tankyrases (Tankyrase 1 and Tankyrase 2), which are enzymes in the poly (ADP-ribose) polymerase (PARP) family (Smith et al., 1998

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regulatory picture is still evolving