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SAMe donates its methyl group to a large variety of acceptor molecules in reactions catalyzed by methyltransferases (MTs), generating S-adenosylhomocysteine (SAH), which is in turn hydrolyzed to homocysteine (Hcy) and adenosine through a reversible reaction catalyzed by SAH hydrolase

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Gene enrichment analysis indicated the involvement of differentially expressed miRNAs in the autophagy pathway, while Western blot experiments showed increased levels of autophagy-related proteins beclin-1 and LC3-II, and a decrease in p62 expression