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In the present study, these cytokines were increased in IC/BPS patients and remained statistically significant in differentiating IC/BPS from OAB in multivariate logistic regression models

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A dysfunctional intestinal barrier can thus have many possible causes and produce symptoms that can range from gastrointestinal disorders such as bloating, cramping, and food intolerance to inflammatory bowel diseases (IBD), systemic, neurological, and psychiatric diseases [17]