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(2021) on dry eye syndrome revealed that oral intake of 12 mg/day for one month significantly improved subjective symptoms (OSDI index), tear film stability (NIBUT and FBUT), and corneal epithelial integrity [149]
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In summary, the key interactions to consider are pyridoxine’s reduction of levodopa and anticonvulsant efficacy, niacinamide’s additive effects on blood pressure, blood sugar, and gout management, and the potential need for B-vitamin repletion in patients on certain medications (diuretics, isoniazid, etc.)
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