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Through another transcription factor by the name of p53: “p53 is a homo-tetrameric transcription factor composed of an N-terminal trans-activation domain (TAD, residues 1–61), a prolin-rich domain (PR, residues 64–92), a central DNA-binding domain (DBD, residues 93–293) followed by a tetramerization domain (TD, residues 325–355) and the C-terminal negative regulatory domain (NRD, residues 367–393) (Fig