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174 Once activated, caspase-8 triggers downstream effector caspases, either directly via proteolytic cleavage or indirectly by cleaving BH3-interacting domain (BID) to its truncated form, which mediates apoptotic cell death via the mitochondria-dependent pathway

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Clonidine is a centrally acting α₂-adrenergic and imidazoline (I₁) receptor agonist that reduces central sympathetic outflow and norepinephrine release, resulting in decreased heart rate and peripheral vascular resistance