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High levels of Hcy can activate the expression and release of inflammatory factors, leading to vascular endothelial dysfunction ( in vitro studies have corroborated the ability of Hcy to induce the release of inflammatory cytokines from ECs, including interleukin-6, interleukin-8, and tumor necrosis factor-α (Kamat et al., 2013
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B-cell aplasia (lack of B cells) can persist for months, especially with anti-CD19 therapies
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