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Moving forward, an integrative approach combining metabolic reprogramming, immunomodulation, and targeted inhibition of CSC vulnerabilities is essential for developing effective CSC-directed therapies

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The methylation cycle stalls, and folate becomes trapped in an unusable state—a phenomenon clinically referred to as the "folate trap." Because the body can no longer produce adequate amounts of SAMe, the synthesis of crucial neurotransmitters drops dramatically

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