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Although the concentrations and doses used in some studies do not always correlate to the human scenario, the mitochondrial abnormalities evoked by MDMA are well described and are in part responsible for its mechanism of toxicity

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In mice, there was increased glial response, decreased expression of EAAT1 and EAAT2, but increased expression of EAAT3 at 28 days after SNI, suggesting compensatory mechanisms are involved in the regulation of these EAATs