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The most extensively documented biological effects of BPC-157 in the published research literature are its gastrointestinal cytoprotective properties and with a large body of research from the Sikiric laboratory characterising protection against ethanol-induced gastric lesions, NSAID-induced gastric and intestinal damage, stress-induced ulceration, and inflammatory bowel disease models in rodents

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Similarly, significant expression of ornithine transaminase 1 (OAT1) would restrict the anaplerotic glutamate pool by diversion of the metabolite glutamate-5-semialdehyde into the ornithine/urea cycle

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