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Although, like other SLC22 family members, SLC22A4 is capable of transporting multiple substrates, the transport efficiencies for other confirmed substrates are orders of magnitude lower than that of ergothioneine, and increasing evidence from independent laboratories demonstrates SLC22A4 is highly specific for ergothioneine (Reference Yee, Buitrago and Stecula28,Reference Tschirka, Kreisor and Betz31,Reference Tucker, Cheah and Halliwell32)

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Niacinamide + vitamin C: While not necessarily a concern, unstable vitamin C (ascorbic acid) might react with niacinamide in poorly designed formulations