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Not everyone will experience this, and it appears to be less common than side effects such as nausea or abdominal pain
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Possible explanations include that mono-ubiquitinated uS3 may be more susceptible to de-ubiquitination in the absence of poly-ubiquitination, or that Hel2 and Fap1 might indirectly affect the activity, recruitment, or stability of Mag2
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