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Researchers administered 15 mg/kg of GHK-Cu to aged (20-21 month) mice via two distinct paradigms: a short-term, 5-day intraperitoneal (IP) injection series, and a long-term, 8-week intranasal (IN) atomization protocol
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Our previous studies, using in vitro cell culture as well as in vivo animal models have also demonstrated that enzymes cytochrome c oxidase (Complex IV) and aconitase are extremely sensitive to mitochondrial-ROS induced oxidative stress in comparison to other complexes [23],[38],[42],[43]
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