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In a 52-week, randomized, double-blind, placebo-controlled study in healthy men, finasteride (5 mg PO once daily) significantly decreased total sperm count (-34.3%) compared to baseline at 26 weeks but not at 52 weeks or at the 24-week follow-up
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Further studies also suggest potential downstream signaling through the JAK-STAT pathway, which could influence the transcription of IGF-I
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