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However, the certain evidence whether the inhibition of ADO-mediated signaling pathway has a direct impact on anti-MM activities of CD38 mAbs is still confusing because of the technical challenges of direct measurement of ADO level in patients [84, 85]

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In patients with metformin-induced vitamin B12 deficiency, vitamin B12 supplementation offers a simple, safe and effective means of preventing the development or the worsening of peripheral nerve damage, anemia and/or other clinical manifestations of vitamin B12 deficiency