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Mechanistically, CC0651 inserts into a cryptic binding pocket in CDC34 distant from the catalytic site, causing conformational rearrangement that interferes with the discharge of charged ubiquitin to acceptor lysine residues
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Mechanistically, one of the ways in which CO may inhibit cancer invasion and metastasis is through inhibition of EMT, as was demonstrated in models of pancreatic (Yan, Du et al
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