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A 2016 open-label single-arm trial by Handog and colleagues in the International Journal of Dermatology administered an oral glutathione lozenge daily for 8 weeks to 30 Filipino women and reported significant decreases in melanin indices from baseline, evident as early as 2 weeks, with no serious adverse events or abnormal laboratory findings — though the open-label single-arm design without a placebo comparator limits causal inference