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This promoter is active in neural crest cells, and driving MYCN overexpression in these progenitor cells of NB causes the animals (Th- MYCN ) to develop tumors that closely resemble human NB ( in vitro

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Activation of ADRB2 counteracted the behavioral and synaptic deficits in FTO-deficient mice, with the ADRB2 agonist formoterol alleviating depression-like behavior and restoring dendritic spine density, while an antagonist blocked these effects