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These cells can adopt different phenotypes involved in AMD pathogenesis, where the phenotype M1 is the one pro-inflammatory leading to the expression of CD16, IL-1β, IL-6, tumor necrosis factor-α, and inducible nitric oxide synthase, 128–130 while the M2 is the anti-inflammatory phenotype upregulating arginase1, mannose receptor, and IL-10

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Anti-aging peptides are short amino acid chains that signal specific cellular processes involved in aging