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Control: Vehicle-treated control, TMZ: temozolomide IC 50 : 250.2 μM, etoposide IC 50 : 6.49 μM Figure 7: a ) Relative fold change of VEGF , HIF1-α , MMP3 , and MMP9 in EP- and TMZ-treated U87-R and U87 cells as determined by quantitative real-time PCR