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During new bone formation some osteoblasts are encased by osteoid and differentiate to dendritic osteocytes that end up within a three-dimensional fluid-filled lacuno-canalicular system, which spans through the entire bone matrix

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Furthermore, studies showed that purified prothymosin α (ProTα), the precursor of thymosin α1 (Tα1), is able to regulate the defective phenotype of monocytes in MS impacting T cell activation (Reclos et al., 1987, Baxevanis et al., 1990)

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