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The treatment group lost 2.8kg more fat mass than placebo (5.2kg vs 2.4kg), measured by DEXA scan

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Some patients feel as though they want more frequent injections, and occasionally we test levels to see if they are receiving adequate replacement, but I’m not sure how strong the evidence is to support this.’ GPs should consider periodic vitamin B12 testing of higher-risk patients who take metformin, even if they don’t display symptoms of deficiency, the UK medicines regulator said earlier this year