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1 Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK 2 Department of Physiology, Anatomy and Cellular Biology, University Pablo de Olavide, Seville, Spain 3 Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK It has recently been discovered that some forms of timing-dependent long-term depression (t-LTD) require presynaptic N -methyl-d-aspartate (NMDA) receptors